Assistant Research Professor
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
25272
(doi: 10.1073/pnas.2002956117)
The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases
(2020)
(doi: 10.48550/arxiv.2009.14135)
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
Nat Struct Mol Biol
(2020)
27
1125
(doi: 10.1038/s41594-020-0505-6)
Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of Covid Survivors
medRxiv
(2020)
2020.09.20.20196907
(doi: 10.1101/2020.09.20.20196907)
Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum
bioRxiv
(2020)
2020.09.14.296442
(doi: 10.1101/2020.09.14.296442)
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
24251
(doi: 10.1073/pnas.2006684117)
Mechanism, scaling and rates of protein aggregation from in vivo measurements
(2020)
(doi: 10.48550/arxiv.2008.09699)
Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
(2020)
2020.08.13.249862
(doi: 10.1101/2020.08.13.249862)
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses
Chem Sci
(2020)
11
7031
(doi: 10.1039/c9sc05905a)
Identification of on- And off-pathway oligomers in amyloid fibril formation
Chemical science
(2020)
11
6236
(doi: 10.1039/c9sc06501f)
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