Dr Anthony Coyne

Publications

Fragment-Based Development of Small Molecule Inhibitors Targeting <i>Mycobacterium tuberculosis</i> Cholesterol Metabolism.

ME Kavanagh, KJ McLean, SH Gilbert, CN Amadi, M Snee, RB Tunnicliffe, K Arora, HIM Boshoff, A Fanourakis, MJ Rebollo-Lopez, F Ortega, CW Levy, AW Munro, D Leys, C Abell, AG Coyne

Journal of Medicinal Chemistry

(2025)

14416

(doi: 10.1021/acs.jmedchem.5c00478)

Chemistry of “On‐Water” Reactions

AG Coyne

(2025)

(doi: 10.1002/9783527846849.ch2)

Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism.

ME Kavanagh, KJ McLean, SH Gilbert, C Amadi, M Snee, RB Tunnicliffe, K Arora, HI Boshoff, A Fanourakis, MJ Rebello-Lopez, F Ortega-Muro, CW Levy, AW Munro, D Leys, C Abell, AG Coyne

(2024)

(doi: 10.1101/2024.10.28.620643)

A Fragment‐Based Competitive ¹⁹F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling

WJ McCarthy, SE Thomas, T Olaleye, JA Boland, RA Floto, G Williams, TL Blundell, AG Coyne, C Abell

Angewandte Chemie

(2024)

136

e202406846

(doi: 10.1002/ange.202406846)

A Fragment-based Competitive 19F LB-NMR Platform For Hotspot-directed Ligand Profiling

W McCarthy, S Thomas, T Olaleye, J Boland, RA Floto, G Williams, T Blundell, A Coyne, C Abell

Angew Chem Int Ed Engl

(2024)

e202406846

(doi: 10.1002/anie.202406846)

Fragment-Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis

T Kirkman, S Fun Tan, SM Chavez-Pacheco, A Hammer, C Abell, M Tosin, AG Coyne, MVB Dias

Chemmedchem

(2023)

e202300240

(doi: 10.1002/cmdc.202300240)

Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.

J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry

Angew Chem Weinheim Bergstr Ger

(2023)

135

e202300221

(doi: 10.1002/ange.202300221)

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis

MM Katariya, M Snee, RB Tunnicliffe, ME Kavanagh, HIM Boshoff, CN Amadi, CW Levy, AW Munro, C Abell, D Leys, AG Coyne, KJ McLean

Chemistry

(2023)

e202203868

(doi: 10.1002/chem.202203868)

Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target

VM Howieson, J Zeng, J Kloehn, C Spry, C Marchetti, M Lunghi, E Varesio, A Soper, AG Coyne, C Abell, GG van Dooren, KJ Saliba

Int J Parasitol Drugs Drug Resist

(2023)

(doi: 10.1016/j.ijpddr.2023.03.003)

Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**

J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry

Angew Chem Int Ed Engl

(2023)

e202300221

(doi: 10.1002/anie.202300221)

Dr Anthony Coyne

Publications

Postdoctoral researcher

Email address

About the Department

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Study at Cambridge

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Research at Cambridge