Centre for Misfolding Diseases

Dr Anthony Coyne

 

 

Publications

Fragment-based development of small molecule inhibitors targetingMycobacterium tuberculosischolesterol metabolism
ME Kavanagh, KJ McLean, SH Gilbert, C Amadi, M Snee, RB Tunnicliffe, K Arora, HI Boshoff, A Fanourakis, MJ Rebello-Lopez, F Ortega-Muro, CW Levy, AW Munro, D Leys, C Abell, AG Coyne
(2024)
(doi: 10.1101/2024.10.28.620643)
A Fragment‐Based Competitive 19F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling
WJ McCarthy, SE Thomas, T Olaleye, JA Boland, RA Floto, G Williams, TL Blundell, AG Coyne, C Abell
Angewandte Chemie
(2024)
136
(doi: 10.1002/ange.202406846)
A Fragment-Based Competitive 19F LB-NMR Platform For Hotspot-Directed Ligand Profiling.
W McCarthy, S Thomas, T Olaleye, J Boland, RA Floto, G Williams, T Blundell, A Coyne, C Abell
Angewandte Chemie International Edition
(2024)
63
(doi: 10.1002/anie.202406846)
Chemistry of “On-Water” Reactions
AG Coyne
(2024)
(doi: 10.1002/9783527846849.ch2)
Fragment-Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis
T Kirkman, S Fun Tan, SM Chavez-Pacheco, A Hammer, C Abell, M Tosin, AG Coyne, MVB Dias
Chemmedchem
(2023)
18
(doi: 10.1002/cmdc.202300240)
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**
J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry
Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
(2023)
135
(doi: 10.1002/ange.202300221)
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
MM Katariya, M Snee, RB Tunnicliffe, ME Kavanagh, HIM Boshoff, CN Amadi, CW Levy, AW Munro, C Abell, D Leys, AG Coyne, KJ McLean
Chemistry
(2023)
29
(doi: 10.1002/chem.202203868)
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.
VM Howieson, J Zeng, J Kloehn, C Spry, C Marchetti, M Lunghi, E Varesio, A Soper, AG Coyne, C Abell, GG van Dooren, KJ Saliba
International Journal for Parasitology: Drugs and Drug Resistance
(2023)
22
(doi: 10.1016/j.ijpddr.2023.03.003)
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**
J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry
Angewandte Chemie (International ed. in English)
(2023)
62
(doi: 10.1002/anie.202300221)
Microfluidic preparation of composite hydrogel microparticles for the staining of microalgal cells*
T Leontidou, Z Yu, J Hess, K Geisler, AG Smith, A Coyne, C Abell
Colloids and Surfaces B Biointerfaces
(2022)
221
(doi: 10.1016/j.colsurfb.2022.113026)

Postdoctoral researcher

Telephone number

01223 336055

Email address

agc40@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

University Privacy Policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge