Dr Patrick Flagmeier

Research Associate

Education

10/2013 - present University of Cambridge, UK

Doctor of Philosophy (PhD)

10/2011 - 09/2013 Ludwigs-Maximilians-University Munich, Germany

Master of Science Biochemistry

10/2008 - 09/2011 Bielefeld University, Germany

Bachelor of Science Biochemistry

Selected Scholarships

Boehringer Ingelheim Fonds

Bayer Science & Education Foundation

German National Merit Foundation

Publications

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

ED Agerschou, P Flagmeier, T Saridaki, C Galvagnion, D Komnig, L Heid, V Prasad, H Shaykhalishahi, D Willbold, CM Dobson, A Voigt, B Falkenburger, W Hoyer, AK Buell

Elife

(2019)

e46112

(doi: 10.7554/eLife.46112)

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman

Nature Communications

(2019)

1541

(doi: 10.1038/s41467-019-09477-3)

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse

ACS Chemical Neuroscience

(2019)

2374

(doi: 10.1021/acschemneuro.8b00676)

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale

J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman

Nano letters

(2018)

7494

(doi: 10.1021/acs.nanolett.8b02916)

Quantifying Co-Oligomer Formation by α‑Synuclein

M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman

ACS nano

(2018)

10855

(doi: 10.1021/acsnano.8b03575)

Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells

DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks

ChemBioChem

(2018)

2033

(doi: 10.1002/cbic.201800209)

Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson

ACS Chemical Biology

(2018)

2308

(doi: 10.1021/acschembio.8b00466)