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Centre for Misfolding Diseases

Dr Patrick Flagmeier

Research Associate

Education

10/2013 - present               University of Cambridge, UK

                                            Doctor of Philosophy (PhD)

10/2011 - 09/2013              Ludwigs-Maximilians-University Munich, Germany

                                            Master of Science Biochemistry

10/2008 - 09/2011              Bielefeld University, Germany

                                            Bachelor of Science Biochemistry

 

Selected Scholarships

Boehringer Ingelheim Fonds

Bayer Science & Education Foundation

German National Merit Foundation

Publications

Optical structural analysis of individual α-synuclein oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
– Angewandte Chemie (International ed. in English)
(2018)
57,
4886
(doi: 10.1002/anie.201710779)
Inhibiting the Ca2+ influx induced by human CSF
A Drews, S De, P Flagmeier, DC Wirthensohn, W-H Chen, DR Whiten, M Rodrigues, C Vincke, S Muyldermans, RW Paterson, CF Slattery, NC Fox, JM Schott, H Zetterberg, CM Dobson, S Gandhi, D Klenerman
– Cell Rep
(2017)
21,
3310
(doi: 10.1016/j.celrep.2017.11.057)
Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proc Natl Acad Sci U S A
(2017)
114,
8005
(doi: 10.1073/pnas.1700239114)
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angewandte Chemie (International ed. in English)
(2017)
56,
7750
(doi: 10.1002/anie.201700966)
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angewandte Chemie
(2017)
129,
7858
(doi: 10.1002/ange.201700966)
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E1009
(doi: 10.1073/pnas.1610586114)
β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.
JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, M Vendruscolo, TPJ Knowles, CM Dobson, C Galvagnion
– Scientific reports
(2016)
6,
36010
(doi: 10.1038/srep36010)
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, AK Buell, C Galvagnion
– Proc Natl Acad Sci U S A
(2016)
113,
10328
(doi: 10.1073/pnas.1604645113)
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.
C Galvagnion, JWP Brown, MM Ouberai, P Flagmeier, M Vendruscolo, AK Buell, E Sparr, CM Dobson
– Proc Natl Acad Sci U S A
(2016)
113,
7065
(doi: 10.1073/pnas.1601899113)
Protein microgels from amyloid fibril networks.
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles
– ACS nano
(2015)
9,
43
(doi: 10.1021/nn504869d)
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Postdoctoral researcher

Telephone number

01223 763845 (shared)

College

St John's College

    Study at Cambridge

    About the University

    Research at Cambridge