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Centre for Misfolding Diseases

Dr Nunilo Cremades

Research Fellow

Publications

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.
G Tóth, T Neumann, A Berthet, E Masliah, B Spencer, J Tao, MF Jobling, SJ Gardai, CW Bertoncini, N Cremades, M Bova, S Ballaron, X-H Chen, W Mao, P Nguyen, MC Tabios, MA Tambe, J-C Rochet, H-D Junker, D Schwizer, R Sekul, I Ott, JP Anderson, B Szoke, W Hoffman, J Christodoulou, T Yednock, DA Agard, D Schenk, L McConlogue
– Sci Rep
(2019)
9,
16947
(doi: 10.1038/s41598-019-52598-4)
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
– ACS Chemical Biology
(2018)
13,
2308
(doi: 10.1021/acschembio.8b00466)
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, C Cecchi, M Vendruscolo, F Chiti, N Cremades, L Ying, CM Dobson, A De Simone
– Science
(2017)
358,
1440
(doi: 10.1126/science.aan6160)
The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases
N Cremades, CM Dobson
– Neurobiol Dis
(2017)
109,
178
(doi: 10.1016/j.nbd.2017.07.009)
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman
– ACS Chemical Neuroscience
(2016)
7,
399
(doi: 10.1021/acschemneuro.5b00324)
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.
E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, MH Horrocks, B Banushi, D Little, MJ Devine, P Gissen, D Klenerman, CM Dobson, NW Wood, S Gandhi, AY Abramov
– Antioxidants & Redox Signaling
(2016)
24,
376
(doi: 10.1089/ars.2015.6343)
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
– Scientific reports
(2015)
5,
16696
(doi: 10.1038/srep16696)
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman
– Analytical Chemistry
(2015)
87,
8818
(doi: 10.1021/acs.analchem.5b01811)
Cell surface localised Hsp70 is a cancer specific regulator of clathrin‐independent endocytosis
B Nimmervoll, LA Chtcheglova, K Juhasz, N Cremades, FA Aprile, A Sonnleitner, P Hinterdorfer, L Vigh, J Preiner, Z Balogi
– FEBS Lett
(2015)
589,
2747
(doi: 10.1016/j.febslet.2015.07.037)
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences
(2015)
112,
e1994
(doi: 10.1073/pnas.1421204112)
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