Centre for Misfolding Diseases

Dr Sarah Meehan

Royal Society Dororthy Hodgkin Research Fellow

Publications

Metastability of native proteins and the phenomenon of amyloid formation.
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, SL Shammas, CA Waudby, MF Mossuto, S Meehan, SL Gras, J Christodoulou, SJ Anthony-Cahill, PD Barker, M Vendruscolo, CM Dobson
J Am Chem Soc
(2011)
133
(doi: 10.1021/ja2017703)
Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action
B Mannini, S Campioni, M Boninsegna, E Palagano, R Cascella, M Zampagni, A Penco, M Wilson, S Meehan, C Roodveldt, A Relini, C Cecchi, F Chiti
FEBS JOURNAL
(2011)
278
Iron Promotes the Toxicity of Amyloid beta Peptide by Impeding Its Ordered Aggregation
B Liu, A Moloney, S Meehan, K Morris, SE Thomas, LC Serpell, R Hider, SJ Marciniak, DA Lomas, DC Crowther
J Biol Chem
(2010)
286
(doi: 10.1074/jbc.m110.158980)
The interaction of unfolding α-lactalbumin and malate dehydrogenase with the molecular chaperone αB-crystallin: a light and X-ray scattering investigation.
JW Regini, H Ecroyd, S Meehan, K Bremmell, MJ Clarke, D Lammie, T Wess, JA Carver
Molecular Vision
(2010)
16
Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody
EJ De Genst, T Guilliams, J Wellens, EM O'Day, CA Waudby, S Meehan, M Dumoulin, S-TD Hsu, N Cremades, KHG Verschueren, E Pardon, L Wyns, J Steyaert, J Christodoulou, CM Dobson
Journal of molecular biology
(2010)
402
(doi: 10.1016/j.jmb.2010.07.001)
The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation
CA Waudby, TPJ Knowles, GL Devlin, JN Skepper, H Ecroyd, JA Carver, ME Welland, J Christodoulou, CM Dobson, S Meehan
Biophysical Journal
(2010)
98
(doi: 10.1016/j.bpj.2009.10.056)
Imaging Amyloid Fibrils within Cells Using a Se-Labelling Strategy
AE Porter, TPJ Knowles, K Muller, S Meehan, E McGuire, J Skepper, ME Welland, CM Dobson
Journal of molecular biology
(2009)
392
(doi: 10.1016/j.jmb.2009.07.061)
Protein nanofibres of defined morphology prepared from mixtures of crude crystallins
M Garvey, SL Gras, S Meehan, SJ Meade, JA Carver, JA Gerrard
International Journal of Nanotechnology
(2009)
6
(doi: 10.1504/ijnt.2009.022918)
alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species.
JJ Yerbury, JR Kumita, S Meehan, CM Dobson, MR Wilson
Journal of Biological Chemistry
(2008)
284
(doi: 10.1074/jbc.m807242200)
Role of Intermolecular Forces in Defining Material Properties of Protein Nanofibrils
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, CM Dobson, ME Welland
Science (New York, N.Y.)
(2007)
318
(doi: 10.1126/science.1150057)

Postdoctoral researcher

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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