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Centre for Misfolding Diseases

Research Associate

Publications

Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α‑Synuclein and Polyglutamine in Aging Caenorhabditis elegans
RF Laine, T Sinnige, KY Ma, AJ Haack, C Poudel, P Gaida, N Curry, M Perni, EAA Nollen, CM Dobson, M Vendruscolo, GS Kaminski Schierle, CF Kaminski
– ACS chemical biology
(2019)
14,
1628
Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response.
T Sinnige, P Ciryam, S Casford, CM Dobson, M de Bono, M Vendruscolo
– PLoS ONE
(2019)
14,
e0217746
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.
C Huang, S Wagner-Valladolid, AD Stephens, R Jung, C Poudel, T Sinnige, MC Lechler, N Schlörit, M Lu, RF Laine, CH Michel, M Vendruscolo, CF Kaminski, GS Kaminski Schierle, DC David
– Elife
(2019)
8,
e43059
Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR
C Pinto, D Mance, T Sinnige, M Daniëls, M Weingarth, M Baldus
– Nat Commun
(2018)
9,
4135
Fast fluorescence lifetime imaging reveals the aggregation processes of α-synuclein and polyglutamine in aging Caenorhabditis elegans
R Laine, T Sinnige, KY Ma, A Haack, C Poudel, P Gaida, N Curry, M Perni, EAA Nollen, C Dobson, M Vendruscolo, G Kaminski Schierle, C Kaminski
(2018)
Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans
T Sinnige, RF Laine, KY Ma, AJ Haack, P Gaida, N Curry, M Perni, EAA Nollen, CM Dobson, M Vendruscolo, GSK Schierle, CF Kaminski
– BIOPHYSICAL JOURNAL
(2018)
114,
350A
Combined 1H-Detected Solid-State NMR Spectroscopy and Electron Cryotomography to Study Membrane Proteins across Resolutions in Native Environments
LA Baker, T Sinnige, P Schellenberger, J de Keyzer, CA Siebert, AJM Driessen, M Baldus, K Grünewald
– Structure (London, England : 1993)
(2017)
26,
161
Effects of Amyloid-Beta Expression on Neuronal Signalling Pathways in a Novel C. elegans Model of Alzheimer's Disease
T Sinnige, P Ciryam, CM Dobson, M de Bono, M Vendruscolo
– Biophysical Journal
(2017)
112,
159A
An Efficient Labelling Approach to Harness Backbone and Side‐Chain Protons in 1H‐Detected Solid‐State NMR Spectroscopy
D Mance, T Sinnige, M Kaplan, S Narasimhan, M Daniëls, K Houben, M Baldus, M Weingarth
– Angewandte Chemie International Edition
(2015)
54,
15799
Conformational Plasticity of the POTRA 5 Domain in the Outer Membrane Protein Assembly Factor BamA
T Sinnige, M Weingarth, M Daniëls, R Boelens, AMJJ Bonvin, K Houben, M Baldus
– Structure (London, England : 1993)
(2015)
23,
1317
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Postdoctoral researcher

Telephone number

01223 763842