Dr Seema Qamar

Research Associate

Publications

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes

Y Li, SHJ Lu, CJ Tsai, C Bohm, S Qamar, RB Dodd, W Meadows, A Jeon, A McLeod, F Chen, M Arimon, O Berezovska, BT Hyman, T Tomita, T Iwatsubo, CM Johnson, LA Farrer, G Schmitt-Ulms, PE Fraser, PH St George-Hyslop

Structure

(2014)

125

(doi: 10.1016/j.str.2013.09.018)

Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2

AHW Jeon, C Böhm, F Chen, H Huo, X Ruan, CH Ren, K Ho, S Qamar, PM Mathews, PE Fraser, HTJ Mount, P St George-Hyslop, G Schmitt-Ulms

J Biol Chem

(2013)

288

15352

(doi: 10.1074/jbc.M112.441840)

Single Molecule Characterization of the Interactions between Amyloid-β Peptides and the Membranes of Hippocampal Cells

P Narayan, KA Ganzinger, J McColl, L Weimann, S Meehan, S Qamar, JA Carver, MR Wilson, P St George-Hyslop, CM Dobson, D Klenerman

J Am Chem Soc

(2013)

135

1491

(doi: 10.1021/ja3103567)

Vigilin interacts with signal peptide peptidase.

SH-J Lu, AHW Jeon, G Schmitt-Ulms, S Qamar, R Dodd, B McDonald, Y Li, W Meadows, K Cox, C Bohm, F Chen, P Fraser, PS George-Hyslop

Proteome science

(2012)

(doi: 10.1186/1477-5956-10-33)

Investigating the Interaction Between Characterized Amyloid-Beta Oligomers and the Prion Protein Receptor in Live Cells

P Narayan, KA Ganzinger, J McColl, A Drews, RW Clarke, S Qamar, P St. George-Hyslop, D Klenerman

Biophysical Journal

(2012)

102

243a

(doi: 10.1016/j.bpj.2011.11.1339)

Receptor protein tyrosine phosphatases are novel components of a polycystin complex

CA Boucher, HH Ward, RL Case, KS Thurston, X Li, A Needham, E Romero, D Hyink, S Qamar, T Roitbak, S Powell, C Ward, PD Wilson, A Wandinger-Ness, RN Sandford

Biochimica Et Biophysica Acta Molecular Basis of Disease

(2011)

1812

1225

(doi: 10.1016/j.bbadis.2010.11.006)

Single molecule imaging of amyloid-peptide and the prion protein receptor on neurons

J McColl, K Ganzinger, P Narayan, S Qamar, P St George-Hyslop, D Klenerman

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2011)

151

Non-native interactions are critical for mechanical strength in PKD domains.

JR Forman, ZT Yew, S Qamar, RN Sandford, E Paci, J Clarke

Structure

(2009)

1582

(doi: 10.1016/j.str.2009.09.013)

Identification of arginine 331 as an important active site residue in the class II fructose-1,6-bisphosphate aldolase of Escherichia coli.

S Qamar, K Marsh, A Berry

Protein Science

(2008)

154

(doi: 10.1002/pro.5560050119)

Human H⁺ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1

Y Su, KG Blake-Palmer, S Sorrell, B Javid, K Bowers, A Zhou, SH Chang, S Qamar, FE Karet

American Journal of Physiology-Renal Physiology

(2008)

295

F950

(doi: 10.1152/ajprenal.90258.2008)

Dr Seema Qamar

Research Associate

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Research at Cambridge