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Centre for Misfolding Diseases

Dr Seema Qamar

Research Associate

Publications

Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)).
KA Ganzinger, P Narayan, SS Qamar, L Weimann, RT Ranasinghe, A Aguzzi, CM Dobson, J McColl, P St George-Hyslop, D Klenerman
– ChemBioChem
(2014)
15,
2515
(doi: 10.1002/cbic.201402377)
A high‐resolution structure of the EF‐hand domain of human polycystin‐2
MD Allen, S Qamar, MK Vadivelu, RN Sandford, M Bycroft
– Protein science : a publication of the Protein Society
(2014)
23,
1301
(doi: 10.1002/pro.2513)
Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes
Y Li, SHJ Lu, CJ Tsai, C Bohm, S Qamar, RB Dodd, W Meadows, A Jeon, A McLeod, F Chen, M Arimon, O Berezovska, BT Hyman, T Tomita, T Iwatsubo, CM Johnson, LA Farrer, G Schmitt-Ulms, PE Fraser, PH St George-Hyslop
– Structure
(2014)
22,
125
(doi: 10.1016/j.str.2013.09.018)
Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes
Y Li, SH-J Lu, C-J Tsai, C Bohm, S Qamar, RB Dodd, W Meadows, A Jeon, A McLeod, F Chen, M Arimon, O Berezovska, BT Hyman, T Tomita, T Iwatsubo, CM Johnson, LA Farrer, G Schmitt-Ulms, PE Fraser, PH St George-Hyslop
– Structure (London, England : 1993)
(2013)
22,
125
(doi: 10.1016/j.str.2013.09.018)
Interactome Analyses of Mature γ-Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2
AHW Jeon, C Böhm, F Chen, H Huo, X Ruan, CH Ren, K Ho, S Qamar, PM Mathews, PE Fraser, HTJ Mount, P St George-Hyslop, G Schmitt-Ulms
– Journal of Biological Chemistry
(2013)
288,
15352
(doi: 10.1074/jbc.M112.441840)
Single Molecule Characterization of the Interactions between Amyloid‑β Peptides and the Membranes of Hippocampal Cells
P Narayan, KA Ganzinger, J McColl, L Weimann, S Meehan, S Qamar, JA Carver, MR Wilson, P St George-Hyslop, CM Dobson, D Klenerman
– J Am Chem Soc
(2013)
135,
1491
(doi: 10.1021/ja3103567)
Vigilin interacts with signal peptide peptidase
SH-J Lu, AHW Jeon, G Schmitt-Ulms, S Qamar, R Dodd, B McDonald, Y Li, W Meadows, K Cox, C Bohm, F Chen, P Fraser, PS George-Hyslop
– Proteome Sci
(2012)
10,
33
(doi: 10.1186/1477-5956-10-33)
Investigating the Interaction Between Characterized Amyloid-Beta Oligomers and the Prion Protein Receptor in Live Cells
P Narayan, KA Ganzinger, J McColl, A Drews, RW Clarke, S Qamar, P St George-Hyslop, D Klenerman
– Biophysical Journal
(2012)
102,
243a
(doi: 10.1016/j.bpj.2011.11.1339)
Receptor protein tyrosine phosphatases are novel components of a polycystin complex
CA Boucher, HH Ward, RL Case, KS Thurston, X Li, A Needham, E Romero, D Hyink, S Qamar, T Roitbak, S Powell, C Ward, PD Wilson, A Wandinger-Ness, RN Sandford
– Biochimica et Biophysica Acta - Molecular Basis of Disease
(2011)
1812,
1225
(doi: 10.1016/j.bbadis.2010.11.006)
Single molecule imaging of amyloid-peptide and the prion protein receptor on neurons
J McColl, K Ganzinger, P Narayan, S Qamar, P St George-Hyslop, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2011)
40,
151
(link to publication)
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Postdoctoral researcher

Telephone number

01223 336359

Email address

College

Queens' College

    Study at Cambridge

    About the University

    Research at Cambridge