Dr Seema Qamar

Research Associate

Publications

Single-MOLECULE IMAGING REVEALS THAT SMALL AMYLOID-β1-42 oligomers interact with the cellular prion protein (PrPC)

KA Ganzinger, P Narayan, SS Qamar, L Weimann, RT Ranasinghe, A Aguzzi, CM Dobson, J McColl, P St George-Hyslop, D Klenerman

Chembiochem : a European journal of chemical biology

(2014)

2515

(doi: 10.1002/cbic.201402377)

A high-resolution structure of the EF-hand domain of human polycystin-2.

MD Allen, S Qamar, MK Vadivelu, RN Sandford, M Bycroft

Protein Science

(2014)

1301

(doi: 10.1002/pro.2513)

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes

Y Li, SHJ Lu, CJ Tsai, C Bohm, S Qamar, RB Dodd, W Meadows, A Jeon, A McLeod, F Chen, M Arimon, O Berezovska, BT Hyman, T Tomita, T Iwatsubo, CM Johnson, LA Farrer, G Schmitt-Ulms, PE Fraser, PH St George-Hyslop

Structure

(2014)

125

(doi: 10.1016/j.str.2013.09.018)

Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes

Y Li, SH-J Lu, C-J Tsai, C Bohm, S Qamar, RB Dodd, W Meadows, A Jeon, A McLeod, F Chen, M Arimon, O Berezovska, BT Hyman, T Tomita, T Iwatsubo, CM Johnson, LA Farrer, G Schmitt-Ulms, PE Fraser, PH St George-Hyslop

Structure

(2013)

125

(doi: 10.1016/j.str.2013.09.018)

Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.

AHW Jeon, C Böhm, F Chen, H Huo, X Ruan, CH Ren, K Ho, S Qamar, PM Mathews, PE Fraser, HTJ Mount, P St George-Hyslop, G Schmitt-Ulms

J Biol Chem

(2013)

288

15352

(doi: 10.1074/jbc.m112.441840)

Single Molecule Characterization of the Interactions between Amyloid-β Peptides and the Membranes of Hippocampal Cells

P Narayan, KA Ganzinger, J McColl, L Weimann, S Meehan, S Qamar, JA Carver, MR Wilson, P St George-Hyslop, CM Dobson, D Klenerman

J Am Chem Soc

(2013)

135

1491

(doi: 10.1021/ja3103567)

Vigilin interacts with signal peptide peptidase

SH-J Lu, AHW Jeon, G Schmitt-Ulms, S Qamar, R Dodd, B McDonald, Y Li, W Meadows, K Cox, C Bohm, F Chen, P Fraser, PS George-Hyslop

Proteome Sci

(2012)

(doi: 10.1186/1477-5956-10-33)

Investigating the Interaction Between Characterized Amyloid-Beta Oligomers and the Prion Protein Receptor in Live Cells

P Narayan, KA Ganzinger, J McColl, A Drews, RW Clarke, S Qamar, P St George-Hyslop, D Klenerman

Biophysical Journal

(2012)

102

243a

(doi: 10.1016/j.bpj.2011.11.1339)

Receptor protein tyrosine phosphatases are novel components of a polycystin complex

CA Boucher, HH Ward, RL Case, KS Thurston, X Li, A Needham, E Romero, D Hyink, S Qamar, T Roitbak, S Powell, C Ward, PD Wilson, A Wandinger-Ness, RN Sandford

Biochimica Et Biophysica Acta Molecular Basis of Disease

(2011)

1812

1225

(doi: 10.1016/j.bbadis.2010.11.006)

Single molecule imaging of amyloid-peptide and the prion protein receptor on neurons

J McColl, K Ganzinger, P Narayan, S Qamar, P St George-Hyslop, D Klenerman

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2011)

151

Dr Seema Qamar

Research Associate

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