Dr Seema Qamar

Research Associate

Publications

Differential interaction with TREM2 modulates microglial uptake of modified Aβ species.

P Joshi, F Riffel, K Satoh, M Enomoto, S Qamar, H Scheiblich, N Villacampa, S Kumar, S Theil, S Parhizkar, C Haass, MT Heneka, PE Fraser, P St George-Hyslop, J Walter

Glia

(2021)

2917

(doi: 10.1002/glia.24077)

Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia.

N Esteras, O Kopach, M Maiolino, V Lariccia, S Amoroso, S Qamar, S Wray, DA Rusakov, M Jaganjac, AY Abramov

Alzheimer's & Dementia

(2021)

318

(doi: 10.1002/alz.12394)

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.

A Vilalta, Y Zhou, J Sevalle, JK Griffin, K Satoh, DH Allendorf, S De, M Puigdellívol, A Bruzas, MA Burguillos, RB Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, PE Fraser, D Klenerman, SF Lee, P St George-Hyslop, GC Brown

Journal of Biological Chemistry

(2021)

296

100631

(doi: 10.1016/j.jbc.2021.100631)

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles

Nat Commun

(2021)

1085

(doi: 10.1038/s41467-021-21181-9)

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, S Alberti, PS George-Hyslop, TPJ Knowles

Nature nanotechnology

(2020)

841

(doi: 10.1038/s41565-020-0731-4)

Inherited and Sporadic Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degenerations arising from Pathological Condensates of Phase Separating Proteins

M Fernandopulle, G Wang, J Nixon-Abell, S Qamar, V Balaji, R Morihara, PH St George-Hyslop

Human molecular genetics

(2019)

r184

(doi: 10.1093/hmg/ddz162)

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Y-C Liao, M Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, T Knowles, M Nelson, M Czekalska, G Musteikyte, R Patel, C Stephens, A Pasolli, L Forrest, PS George-Hyslop, J Lippincott-Schwartz, ME Ward

Cell

(2019)

179

147

(doi: 10.1016/j.cell.2019.08.050)

General sol to gel transition of liquid-liqud phase separated protein under shear

Y Shen, S Qamar, D Vigolo, A Kamada, S Zhang, P St George-Hyslop, T Knowles

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2019)

S73

General sol to gel transition of liquid-liqud phase separated protein under shear

Y Shen, S Qamar, D Vigolo, A Kamada, S Zhang, P St George-Hyslop, T Knowles

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2019)

S227

Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman

ACS chemical neuroscience

(2018)

3060

(doi: 10.1021/acschemneuro.8b00250)

Dr Seema Qamar

Research Associate

Publications

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Research at Cambridge