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Centre for Misfolding Diseases

Dr Seema Qamar

Research Associate

Publications

Differential interaction with TREM2 modulates microglial uptake of modified Aβ species
P Joshi, F Riffel, K Satoh, M Enomoto, S Qamar, H Scheiblich, N Villacampa, S Kumar, S Theil, S Parhizkar, C Haass, MT Heneka, PE Fraser, P St George-Hyslop, J Walter
– Glia
(2021)
69,
2917
(doi: 10.1002/glia.24077)
Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia
N Esteras, O Kopach, M Maiolino, V Lariccia, S Amoroso, S Qamar, S Wray, DA Rusakov, M Jaganjac, AY Abramov
– Alzheimer's and Dementia
(2021)
18,
318
(doi: 10.1002/alz.12394)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation
A Vilalta, Y Zhou, J Sevalle, JK Griffin, K Satoh, DH Allendorf, S De, M Puigdellívol, A Bruzas, MA Burguillos, RB Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, PE Fraser, D Klenerman, SF Lee, P St George-Hyslop, GC Brown
– J Biol Chem
(2021)
296,
100631
(doi: 10.1016/j.jbc.2021.100631)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
– Nat Commun
(2021)
12,
1085
(doi: 10.1038/s41467-021-21181-9)
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition
Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, S Alberti, PS George-Hyslop, TPJ Knowles
– Nat Nanotechnol
(2020)
15,
841
(doi: 10.1038/s41565-020-0731-4)
Inherited and Sporadic Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degenerations arising from Pathological Condensates of Phase Separating Proteins.
M Fernandopulle, G Wang, J Nixon-Abell, S Qamar, V Balaji, R Morihara, PH St George-Hyslop
– Human molecular genetics
(2019)
28,
r184
(doi: 10.1093/hmg/ddz162)
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Y-C Liao, M Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, T Knowles, M Nelson, M Czekalska, G Musteikyte, R Patel, C Stephens, A Pasolli, L Forrest, PS George-Hyslop, J Lippincott-Schwartz, ME Ward
– Cell
(2019)
179,
147
(doi: 10.1016/j.cell.2019.08.050)
General sol to gel transition of liquid-liqud phase separated protein under shear
Y Shen, S Qamar, D Vigolo, A Kamada, S Zhang, P St George-Hyslop, T Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2019)
48,
S227
(link to publication)
General sol to gel transition of liquid-liqud phase separated protein under shear
Y Shen, S Qamar, D Vigolo, A Kamada, S Zhang, P St George-Hyslop, T Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2019)
48,
S73
(link to publication)
Oligomer Diversity during the Aggregation of the Repeat Region of Tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
– ACS Chemical Neuroscience
(2018)
9,
3060
(doi: 10.1021/acschemneuro.8b00250)
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Postdoctoral researcher

Telephone number

01223 336359

Email address

College

Queens' College

    Study at Cambridge

    About the University

    Research at Cambridge