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Centre for Misfolding Diseases

Publications

Computational maturation of a single-domain antibody against Aβ42 aggregation
J Lin, C Figazzolo, MA Metrick, P Sormanni, M Vendruscolo
– Chemical Science
(2021)
12,
13940
A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases.
MA Metrick, NDC Ferreira, E Saijo, A Kraus, K Newell, G Zanusso, M Vendruscolo, B Ghetti, B Caughey
– Acta Neuropathol Commun
(2020)
8,
22
Correction to: 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
E Saijo, MA Metrick, S Koga, P Parchi, I Litvan, S Spina, A Boxer, JC Rojas, D Galasko, A Kraus, M Rossi, K Newell, G Zanusso, LT Grinberg, WW Seeley, B Ghetti, DW Dickson, B Caughey
– Acta Neuropathol
(2019)
139,
79
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons.
MA Metrick, N do Carmo Ferreira, E Saijo, AG Hughson, A Kraus, C Orrú, MW Miller, G Zanusso, B Ghetti, M Vendruscolo, B Caughey
– Proceedings of the National Academy of Sciences of the United States of America
(2019)
116,
23029
4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
E Saijo, MA Metrick, S Koga, P Parchi, I Litvan, S Spina, A Boxer, JC Rojas, D Galasko, A Kraus, M Rossi, K Newell, G Zanusso, LT Grinberg, WW Seeley, B Ghetti, DW Dickson, B Caughey
– Acta Neuropathol
(2019)
139,
63
Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates
E Saijo, BR Groveman, A Kraus, M Metrick, CD Orrù, AG Hughson, B Caughey
(2019)
1873,
19
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease.
A Kraus, E Saijo, MA Metrick, K Newell, CJ Sigurdson, G Zanusso, B Ghetti, B Caughey
– Acta Neuropathol
(2018)
137,
585
Hofmeister Ion-Induced Changes in Water Structure Correlate with Changes in Solvation of an Aggregated Protein Complex.
TP Light, KM Corbett, MA Metrick, G MacDonald
– Langmuir
(2016)
32,
1360
Variable-Field Analytical Ultracentrifugation: I. Time-Optimized Sedimentation Equilibrium.
J Ma, M Metrick, R Ghirlando, H Zhao, P Schuck
– Biophysical Journal
(2015)
109,
827
Hofmeister ion effects on the solvation and thermal stability of model proteins lysozyme and myoglobin
MA Metrick, G MacDonald
– Colloids and Surfaces A: Physicochemical and Engineering Aspects
(2015)
469,
242
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