Centre for Misfolding Diseases

Dr Minkoo Ahn

Research Associate

Publications

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
Nature Communications
(2019)
10
(doi: 10.1038/s41467-018-07699-5)
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation
M Ahn, BI Lee, S Chia, J Habchi, JR Kumita, M Vendruscolo, CM Dobson, CB Park
Chemical Communications
(2019)
55
(doi: 10.1039/c8cc09288e)
Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1253)
Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.
M Ahn, CA Waudby, A Bernardo-Gancedo, E De Genst, A Dhulesia, X Salvatella, J Christodoulou, CM Dobson, JR Kumita
Scientific Reports
(2017)
7
(doi: 10.1038/s41598-017-14739-5)
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Proceedings of the National Academy of Sciences
(2016)
114
(doi: 10.1073/pnas.1615613114)
The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.
M Ahn, CL Hagan, A Bernardo-Gancedo, E De Genst, FN Newby, J Christodoulou, A Dhulesia, M Dumoulin, CV Robinson, CM Dobson, JR Kumita
Biophys J
(2016)
111
(doi: 10.1016/j.bpj.2016.10.028)
Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme
M Ahn, E De Genst, GS Kaminski Schierle, M Erdelyi, CF Kaminski, CM Dobson, JR Kumita
Plos One
(2012)
7
(doi: 10.1371/journal.pone.0050192)
Investigating the effects of a chemical probe on the native structure and misfolding of human lysozyme
M Ahn, E De Genst, GK Schierle, M Erdelyi, C Kaminski, C Dobson, J Kumita
PROTEIN SCIENCE
(2012)
21
Removal of intact β2‐microglobulin at neutral ph by using seed‐conjugated polymer beads prepared with β2‐microglobulin‐derived peptide (58–67)
S Kang, JE Yang, J Kim, M Ahn, HJ Koo, M Kim, Y-S Lee, SR Paik
Biotechnology Progress
(2011)
27
(doi: 10.1002/btpr.562)
Nanoporous protein matrix made of amyloid fibrils of β2‐microglobulin
M Ahn, S Kang, HJ Koo, J-H Lee, Y-S Lee, SR Paik
Biotechnology Progress
(2010)
26
(doi: 10.1002/btpr.466)

Postdoctoral researcher

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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