Karen Stroobants is a post-doctoral researcher in the Centre for Protein Misfolding Diseases at the Chemistry Department of the University of Cambridge. With a strong background in biophysical characterisation of proteins, she recently engaged in the study of membrane protein aggregates and their potential role in neurodegenerative diseases. The formation of aggregates has been identified as a crucial common feature in disorders such as Alzheimer’s and Parkinson’s diseases, and amyloid formation was studied extensively for few specific associated proteins. More recently, widespread aggregation of numerous other proteins, with high vulnerabilities for aggregation, was proposed to contribute to the disease progression. Membrane proteins are among the most aggregation prone proteins and those in the respiratory chain and glucose metabolism were previously associated to pathological pathways. Karen's current research envisions the biophysical characterisation of membrane protein aggregates as well as the establishment of their potential role in neurodegenerative disease pathways.

Publications

Regioselective hydrolysis of human serum albumin by ZrIV- substituted polyoxotungstates at the interface of positively charged protein surface patches and negatively charged amino acid residues
K Stroobants, G Absillis, E Moelants, P Proost, TN Parac-Vogt
Chemistry A European Journal
(2014)
20
Regioselective Hydrolysis of Human Serum Albumin by ZrIV-Substituted Polyoxotungstates at the Interface of Positively Charged Protein Surface Patches and Negatively Charged Amino Acid Residues
K Stroobants, G Absillis, E Moelants, P Proost, TN Parac-Vogt
Chemistry - A European Journal
(2014)
20
Surface charge fit, peptide bond snip: Metal-substituted polyoxometalates as region selective artificial proteases
K Stroobants, G Absillis, T Parac-Vogt, E Moelants, P Proost, G Bruylants
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2014)
19
Hydrolysis of Tetraglycine by a Zr(IV)-Substituted Wells–Dawson Polyoxotungstate Studied by Diffusion Ordered NMR Spectroscopy
K Stroobants, G Absillis, PS Shestakova, R Willem, TN Parac-Vogt
Journal of Cluster Science
(2013)
25
Molecular interactions between serum albumin proteins and Keggin type polyoxometalates studied using luminescence spectroscopy.
V Goovaerts, K Stroobants, G Absillis, TN Parac-Vogt
Physical Chemistry Chemical Physics
(2013)
15
Flanders overrates impact factors
K Stroobants, S Godecharle, S Brouwers
Nature
(2013)
500
Research evaluation: Flanders overrates impact factors.
K Stroobants, S Godecharle, S Brouwers
Nature
(2013)
500
Polyoxometalates as a Novel Class of Artificial Proteases: Selective Hydrolysis of Lysozyme under Physiological pH and Temperature Promoted by a Cerium(IV) Keggin-Type Polyoxometalate
K Stroobants, E Moelants, HGT Ly, P Proost, K Bartik, TN Parac-Vogt
Chemistry - A European Journal
(2013)
19
Hydrolysis of serine-containing peptides at neutral pH promoted by [MoO4]2- oxyanion.
PH Ho, K Stroobants, TN Parac-Vogt
Inorganic chemistry
(2011)
50

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