Centre for Misfolding Diseases

Dr Koki Nakatsu

Publications

Chemical Protein Synthesis via Direction-Switching One-Pot Peptide Ligation Enabled by Orthogonal Cysteinyl Protection.
K Nakatsu, F Yoshitomi, H Onoda, R Shikimachi, K Arita, A Okamoto, H Murakami, G Hayashi
J Am Chem Soc
(2026)
(doi: 10.1021/jacs.5c20510)
Chemical protein synthesis via one-pot multiple peptide ligation strategies
G Hayashi, K Nakatsu, S Suzuki, Y Nakajima
(2024)
(doi: 10.1039/bk9781839169328-00001)
One-pot ligation of multiple peptide segments via N-terminal thiazolidine deprotection chemistry.
G Nakamura, K Nakatsu, G Hayashi
(2024)
698
(doi: 10.1016/bs.mie.2024.04.020)
Repetitive Thiazolidine Deprotection Using a Thioester‐Compatible Aldehyde Scavenger for One‐Pot Multiple Peptide Ligation**
K Nakatsu, A Okamoto, G Hayashi, H Murakami
Angewandte Chemie International Edition
(2022)
61
(doi: 10.1002/anie.202206240)
Fmoc-Compatible and C-terminal-Sequence-Independent Peptide Alkyl Thioester Formation Using Cysteinylprolyl Imide.
K Nakatsu, M Yanase, G Hayashi, A Okamoto
Organic Letters
(2020)
22
(doi: 10.1021/acs.orglett.0c01450)
Toolbox for chemically synthesized histone proteins
K Nakatsu, G Hayashi, A Okamoto
Current opinion in chemical biology
(2020)
58
(doi: 10.1016/j.cbpa.2020.04.016)
Cysteinylprolyl imide (CPI) peptide: a highly reactive and easily accessible crypto-thioester for chemical protein synthesis
M Yanase, K Nakatsu, CJ Cardos, Y Konda, G Hayashi, A Okamoto
Chemical Science
(2019)
10
(doi: 10.1039/c9sc00646j)

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kn448@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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