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Centre for Misfolding Diseases

I am a Research Fellow at St. John's College, Senior Schmidt Science Fellow, and post-doctoral researcher at the Centre for Misfolding Diseases, Department of Chemistry. My research focusses on developing new experimental and predictive computational methods for examining the behaviour of biological molecules and systems, in particular proteins.

Proteins are the executive molecules of life that through diverse set of highly integrated and tightly regulated interactions set the molecular basis for our well-being. Yet the diverse and dynamic nature of proteins has made it challenging to devise methods that could be effectively used for understanding their roles in human health and disease. By bringing data science, machine learning, computational biology and chemistry approaches together with experimental sciences, I develop new in silico capabilities for probing the key molecular interactions that underpin biological function. I am particularly interested in modelling biomolecular phase separation and condensation processes and in understanding the biological rules and sequence grammar that govern the formation of such condensates. I further aim to understand how these systems can be modulated by small molecules as this development could open up the possibility for discovering therapeutics against biomolecular condensates and biological targets that have remained undruggable using conventional approaches.

I have co-authored over 40 peer-reviewed publications, book chapters and patents. Full list of my publications is available from: https://scholar.google.co.uk/citations?hl=en&user=7OQGF4oAAAAJ

Publications

Rapid structural, kinetic, and immunochemical analysis of alpha-synuclein oligomers in solution
WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, JR Kumita, CM Dobson, TPJ Knowles
– Nano Letters
(2020)
20,
8163
Real-Time Highly-Sensitive Protein Quantification Through On-Chip Chemiluminescence
HK Chiu, T Kartanas, S R. A. Devenish, K Saar, C Mouritsen Luxhøj, T Knowles
(2020)
Multidimensional protein characterisation using microfluidic post-column analysis
T Scheidt, T Kartanas, Q Peter, MM Schneider, KL Saar, T Müller, PK Challa, A Levin, S Devenish, TPJ Knowles
– Lab Chip
(2020)
20,
2663
Direct digital sensing of protein biomarkers in solution
G Krainer, K Saar, W Arter, T Welsh, M Czekalska, RPB Jacquat, Q Peter, W Traberg, W Traberg, A Pujari, A Jayaram, P Challa, C Taylor, L-M van der Linden, T Franzmann, R Owens, S Alberti, D Klenerman, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2020)
120,
2020.05.24.113498
Rapid two-dimensional characterisation of proteins in solution.
KL Saar, Q Peter, T Müller, PK Challa, TW Herling, TPJ Knowles
– Microsystems & nanoengineering
(2019)
5,
33
Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis.
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
– Analyst
(2019)
144,
4413
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez-Osés, GJL Bernardes
– Angewandte Chemie International Edition
(2019)
58,
6640
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez‐Osés, GJL Bernardes
– Angewandte Chemie
(2019)
131,
6712
Analysis of αb-crystallin polydispersity in solution through native microfluidic electrophoresis
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
– Analyst
(2019)
144,
4413
Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing
WE Arter, J Charmet, J Kong, KL Saar, TW Herling, T Müller, UF Keyser, TPJ Knowles
– Analytical chemistry
(2018)
90,
10302
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01223 336359

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