Jonathan Breiter

Publications

Microglial Activation and Alpha-Synuclein Oligomers Drive the Early Inflammatory Phase of Parkinson's Disease

C Toomey, J Evans, M Grant-Peters, J Beckwith, R Popovic, J Breiter, J Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, E Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, R Saleeb, H Lucas-Clarke, A Penverne, K D'sa, CW Pang, M Horrocks, M Vendruscolo, N Wood, S Lee, M Ryten, S Gandhi

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

(2026)

In Situ Quantification of Nanoscale Alpha-Synuclein Assemblies

JC Breiter

(2025)

(doi: 10.17863/CAM.132511)

Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal

MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl

(2025)

(doi: 10.1101/2025.09.08.674880)

Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue

R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee

Nature Biomedical Engineering

(2025)

1222

(doi: 10.1038/s41551-025-01496-4)

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease

JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi

(2025)

(doi: 10.1101/2025.08.25.671921)

α-Synuclein driven cell susceptibility in Parkinson’s disease

JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee

(2025)

(doi: 10.1101/2025.08.19.670819)

Optimizing performance characteristics of antibodies for single-molecule quantitative bioimaging

JC Breiter, C Loiseau, JS Beckwith, R Andrews, B Fu, PJ Magill, SF Lee, M Vendruscolo

FEBS OPEN BIO

(2024)

RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.

B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee

Journal of Physical Chemistry B

(2024)

128

3585

(doi: 10.1021/acs.jpcb.4c00174)

Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue

R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, R Tian, JS Beckwith, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee

(2024)

(doi: 10.1101/2024.02.17.580698)

RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds

B Fu, EE Brock, R Andrews, JC Breiter, R Tian, CE Toomey, J Lachica, T Lashley, M Ryten, NW Wood, M Vendruscolo, S Gandhi, LE Weiss, JS Beckwith, SF Lee

(2023)

(doi: 10.1101/2023.12.18.572148)

Jonathan Breiter

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Research at Cambridge