Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases.
– J Chem Phys
(2021)
154,
125101
(doi: 10.1063/5.0031650)
Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans.
– Proceedings of the National Academy of Sciences
(2021)
118,
e2021888118
(doi: 10.1073/pnas.2021888118)
In situ kinetic measurements of α-synuclein aggregation reveal large population of shortlived oligomers
– PloS one
(2021)
16,
e0245548
(doi: 10.1371/journal.pone.0245548)
DETECTION AND QUANTIFICATION OF IMMUNOLOGICALLY RELEVANT ALLOANTIBODY-HLA INTERACTIONS USING MICROFLUIDIC ANTIBODY AFFINITY PROFILING
– TRANSPLANT INTERNATIONAL
(2021)
34,
245
Amplification, not spreading limits rate of tau aggregate accumulation in Alzheimer’s disease
(2020)
2020.11.16.384727
(doi: 10.1101/2020.11.16.384727)
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils
– Proceedings of the National Academy of Sciences of the United States of America
(2020)
117,
25272
(doi: 10.1073/pnas.2002956117)
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.
– Nature structural & molecular biology
(2020)
27,
1125
(doi: 10.1038/s41594-020-0505-6)
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.
– Proceedings of the National Academy of Sciences
(2020)
117,
24251
(doi: 10.1073/pnas.2006684117)
Mechanism, scaling and rates of protein aggregation from in vivo
measurements
(2020)
Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
(2020)
2020.08.13.249862
(doi: 10.1101/2020.08.13.249862)
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