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Centre for Misfolding Diseases

Catherine Kejia Xu

Research Associate

Publications

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells.
R Cascella, SW Chen, A Bigi, JD Camino, CK Xu, CM Dobson, F Chiti, N Cremades, C Cecchi
– Nature Communications
(2021)
12,
1814
(doi: 10.1038/s41467-021-21937-3)
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, S Sarwat, P Joshi, JR Kumita, S Linse, J Habchi, TPJ Knowles, B Mannini, CM Dobson, M Vendruscolo
– Communications Biology
(2021)
4,
19
(doi: 10.1038/s42003-020-01490-3)
Interactions of α-synuclein oligomers with lipid membranes
G Musteikytė, AK Jayaram, CK Xu, M Vendruscolo, G Krainer, TPJ Knowles
– Biochimica et Biophysica Acta (BBA) - Biomembranes
(2020)
1863,
183536
(doi: 10.1016/j.bbamem.2020.183536)
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.
WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, JR Kumita, CM Dobson, TPJ Knowles
– Nano Letters
(2020)
20,
8163
(doi: 10.1021/acs.nanolett.0c03260)
Biophysical approaches to characterising protein-protein interactions and intermediate species in protein aggregation
C Xu
(2020)
(doi: 10.17863/CAM.65349)
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, E Sileikis, M Lundqvist, F Qian, T O'Malley, T Bussiere, PH Weinreb, CK Xu, G Meisl, SRA Devenish, TPJ Knowles, O Hansson
– Nature Structural & Molecular Biology
(2020)
27,
1125
(doi: 10.1038/s41594-020-0505-6)
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, SW Chen, J Habchi, A Bigi, RP Kreiser, AK Wright, JA Albright, T Kartanas, JR Kumita, N Cremades, M Zasloff, C Cecchi, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Commun Biol
(2020)
3,
435
(doi: 10.1038/s42003-020-01140-8)
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses.
J Pansieri, IA Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, G Musteikyte, V Smirnovas, MM Schneider, T Scheidt, CK Xu, G Meisl, TPJ Knowles, E Gazit, R Antoine, LA Morozova-Roche
– Chem Sci
(2020)
11,
7031
(doi: 10.1039/c9sc05905a)
ThX-a next-generation probe for the early detection of amyloid aggregates
L-M Needham, J Weber, JA Varela, JWB Fyfe, DT Do, CK Xu, L Tutton, R Cliffe, B Keenlyside, D Klenerman, CM Dobson, CA Hunter, KH Müller, K O'Holleran, SE Bohndiek, TN Snaddon, SF Lee
– Chemical science
(2020)
11,
4578
(doi: 10.1039/c9sc04730a)
Rapid Fractionation and Characterisation of Alpha-Synuclein Oligomers in Solution
W Arter, C Xu, M Castellana-Cruz, T Herling, G Krainer, K Saar, J Kumita, C Dobson, T Knowles
(2020)
2020.03.10.985804
(doi: 10.1101/2020.03.10.985804)
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Postdoctoral researcher

Telephone number

01223 748844

College

Trinity College

    Study at Cambridge

    About the University

    Research at Cambridge