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Centre for Misfolding Diseases

Dr Alexander Buell

Publications

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
– Nature chemical biology
(2015)
11,
229
(doi: 10.1038/nchembio.1750)
Protein Microgels from Amyloid Fibril Networks
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles
– ACS Nano
(2015)
9,
43
(doi: 10.1021/nn504869d)
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
– Nature Chemical Biology
(2015)
11,
229
(doi: 10.1038/nchembio.1750)
Influence of the protein context on the polyglutamine length-dependent elongation of amyloid fibrils.
C Huynen, N Willet, AK Buell, A-S Duwez, C Jerôme, M Dumoulin
– Biochimica et Biophysica Acta - Proteins and Proteomics
(2014)
1854,
239
(doi: 10.1016/j.bbapap.2014.12.002)
Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers
A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, Y Bram, SA Stratford, CM Dobson, TPJ Knowles, E Gazit
– Nat Commun
(2014)
5,
5219
(doi: 10.1038/ncomms6219)
The physical chemistry of the amyloid phenomenon: Thermodynamics and kinetics of fi lamentous protein aggregation
AK Buell, CM Dobson, TPJ Knowles
– Essays Biochem
(2014)
56,
11
(doi: 10.1042/bse0560011)
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, S Linse, CM Dobson
– Proceedings of the National Academy of Sciences
(2014)
111,
7671
(doi: 10.1073/pnas.1315346111)
Spatial propagation of protein polymerization.
SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles
– Physical Review Letters
(2014)
112,
098101
(doi: 10.1103/PhysRevLett.112.098101)
The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen
– Journal of the American Chemical Society
(2014)
136,
3859
(doi: 10.1021/ja411577t)
Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
– PloS one
(2014)
9,
e87133
(doi: 10.1371/journal.pone.0087133)
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