Dr Alexander Buell

Publications

Protein Microgels from Amyloid Fibril Networks

U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles

ACS nano

(2015)

(doi: 10.1021/nn504869d)

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, CM Dobson

Nature Chemical Biology

(2015)

229

(doi: 10.1038/nchembio.1750)

Influence of the protein context on the polyglutamine length-dependent elongation of amyloid fibrils

C Huynen, N Willet, AK Buell, A-S Duwez, C Jerôme, M Dumoulin

Biochimica et Biophysica Acta

(2014)

1854

239

(doi: 10.1016/j.bbapap.2014.12.002)

Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, Y Bram, SA Stratford, CM Dobson, TPJ Knowles, E Gazit

Nat Commun

(2014)

5219

(doi: 10.1038/ncomms6219)

The physical chemistry of the amyloid phenomenon: Thermodynamics and kinetics of fi lamentous protein aggregation

AK Buell, CM Dobson, TPJ Knowles

Essays Biochem

(2014)

(doi: 10.1042/bse0560011)

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation.

AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, S Linse, CM Dobson

Proceedings of the National Academy of Sciences of the United States of America

(2014)

111

7671

(doi: 10.1073/pnas.1315346111)

Spatial Propagation of Protein Polymerization

SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles

Physical review letters

(2014)

112

098101

(doi: 10.1103/physrevlett.112.098101)

The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation

N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen

J Am Chem Soc

(2014)

136

3859

(doi: 10.1021/ja411577t)

Targeting the intrinsically disordered structural ensemble of a-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue

PLoS One

(2014)

e87133

(doi: 10.1371/journal.pone.0087133)