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Centre for Misfolding Diseases

Dr Pavan Kumar Challa

Research Associate

My goal is to build a single cell proteomics platform for molecular diagnostics.

Publications

Nanofluidic Traps by Two-Photon Fabrication for Extended Detection of Single Macromolecules and Colloids in Solution
O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, PK Challa, Q Peter, Z Toprakcioglu, CK Xu, UF Keyser, JJ Baumberg, CF Kaminski, TPJ Knowles
– ACS Applied Nano Materials
(2022)
5,
1995
(doi: 10.1021/acsanm.1c03691)
Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems
TA Hakala, EV Yates, PK Challa, Z Toprakcioglu, K Nadendla, D Matak-Vinkovic, CM Dobson, R Martínez, F Corzana, TPJ Knowles, GJL Bernardes
– Journal of the American Chemical Society
(2021)
143,
16401
(doi: 10.1021/jacs.1c03681)
Machine learning-aided protein identification from multidimensional signatures.
Y Zhang, MA Wright, KL Saar, P Challa, AS Morgunov, QAE Peter, S Devenish, CM Dobson, TPJ Knowles
– Lab on a chip
(2021)
21,
2922
(doi: 10.1039/d0lc01148g)
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease
M Perni, A van der Goot, R Limbocker, TJ van Ham, FA Aprile, CK Xu, P Flagmeier, K Thijssen, P Sormanni, G Fusco, SW Chen, PK Challa, JB Kirkegaard, RF Laine, KY Ma, MBD Müller, T Sinnige, JR Kumita, SIA Cohen, R Seinstra, GS Kaminski Schierle, CF Kaminski, D Barbut, A De Simone, TPJ Knowles, M Zasloff, EAA Nollen, M Vendruscolo, CM Dobson
– Front Cell Dev Biol
(2021)
9,
552549
(doi: 10.3389/fcell.2021.552549)
Direct Digital Sensing of Proteins in Solution through Single-Molecule Optofluidics
G Krainer, KL Saar, WE Arter, TPJ Knowles
– Biophysical Journal
(2021)
120,
114A
(doi: 10.1016/j.bpj.2020.11.2269)
Multidimensional protein characterisation using microfluidic post-column analysis.
T Scheidt, T Kartanas, Q Peter, MM Schneider, KL Saar, T Müller, PK Challa, A Levin, S Devenish, TPJ Knowles
– Lab on a chip
(2020)
20,
2663
(doi: 10.1039/d0lc00219d)
Direct digital sensing of protein biomarkers in solution
G Krainer, K Saar, W Arter, T Welsh, M Czekalska, RPB Jacquat, Q Peter, W Traberg, W Traberg, A Pujari, A Jayaram, P Challa, C Taylor, L-M van der Linden, T Franzmann, R Owens, S Alberti, D Klenerman, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2020)
120,
2020.05.24.113498
(doi: 10.1101/2020.05.24.113498)
Attoliter protein nanogels from droplet nanofluidics for intracellular delivery.
Z Toprakcioglu, PK Challa, DB Morse, T Knowles
– Science advances
(2020)
6,
eaay7952
(doi: 10.1126/sciadv.aay7952)
Low-Cost Microfabrication Tool Box
J Charmet, R Rodrigues, E Yildirim, PK Challa, B Roberts, R Dallmann, Y Whulanza
– Micromachines
(2020)
11,
135
(doi: 10.3390/mi11020135)
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature communications
(2019)
10,
225
(doi: 10.1038/s41467-018-07699-5)
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Postdoctoral researcher

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    Research at Cambridge