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Centre for Misfolding Diseases

Dr Janet Kumita

I received an Honours B.Sc. in Biochemistry from the University of Waterloo (Canada) and completed my Ph.D. at the University of Toronto in the laboratory of Prof. G.A. Woolley, where my work involved investigating reversible photo-control of peptide structure and activity. In 2003, I was awarded a NSERC Postdoctoral Fellowship and joined the research group of Prof. C.M. Dobson in the Dept. of Chemistry, University of Cambridge, during which time I have been a Co-researcher Investigator on a BBRSC Project grant and am now a Senior Research Associate in the Centre for Misfolding Diseases. My research interests focus on studying the mechanisms of protein misfolding in globular proteins (specifically human lysozyme and disease-related variants), on a molecular level. We are also looking at different protein misfolding systems (Aβ1-42 and TDP-43) to probe the cellular mechanisms involved in protein misfolding and how biological molecules such as extracellular chaperones modify and influence these processes.


Clusterin protects neurons against intracellular proteotoxicity
JM Gregory, DR Whiten, RA Brown, TP Barros, JR Kumita, JJ Yerbury, S Satapathy, K McDade, C Smith, LM Luheshi, CM Dobson, MR Wilson
– Acta Neuropathologica Communications
Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.
M Ahn, CA Waudby, A Bernardo-Gancedo, E De Genst, A Dhulesia, X Salvatella, J Christodoulou, CM Dobson, JR Kumita
– Scientific reports
The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis.
MA Hanspal, CM Dobson, JJ Yerbury, JR Kumita
– Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Amyloid-like Fibrils from an α-Helical Transmembrane Protein
K Stroobants, JR Kumita, NJ Harris, DY Chirgadze, CM Dobson, PJ Booth, M Vendruscolo
– Biochemistry
Flow cytometric measurement of the cellular propagation of TDP-43 aggregation
R Zeineddine, DR Whiten, NE Farrawell, L McAlary, MA Hanspal, JR Kumita, MR Wilson, JJ Yerbury
– Prion
Inhibition of alpha-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between alpha-Synuclein Species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades
– Biochemistry
The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.
M Ahn, CL Hagan, A Bernardo-Gancedo, E De Genst, FN Newby, J Christodoulou, A Dhulesia, M Dumoulin, CV Robinson, CM Dobson, JR Kumita
– Biophys J
Structural Studies of the Oligomerization Process of Human Cystatin C Variants
Z Pietralik, M Murawska, A Szymanska, JR Kumita, CM Dobson, M Kozak
– Biophysical Journal
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide.
P Aran Terol, JR Kumita, SC Hook, CM Dobson, EK Esbjörner
– Biochemical and Biophysical Research Communications
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Principal Research Associate

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01223 761083

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