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Centre for Misfolding Diseases

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  • Currently displaying 21 - 40 of 1601 publications
Structural basis of synaptic vesicle assembly promoted by alpha-synuclein (vol 7, 12563, 2016)
G Fusco, T Pape, AD Stephens, P Mahou, AR Costa, CF Kaminski, GSK Schierle, M Vendruscolo, G Veglia, CM Dobson, A De Simone
– Nature Communications
(2017)
8,
15667
Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.
R Zeineddine, DR Whiten, NE Farrawell, L McAlary, MA Hanspal, JR Kumita, MR Wilson, JJ Yerbury
– Prion
(2017)
11,
195
The rnf168 paralog rnf169 defines a new class of ubiquitylated histone reader involved in the response to dna damage
J Kitevski-LeBlanc, A Fradet-Turcotte, P Kukic, MD Wilson, G Portella, T Yuwen, S Panier, S Duan, MD Canny, H van Ingen, CH Arrowsmith, JL Rubinstein, M Vendruscolo, D Durocher, LE Kay
– eLife
(2017)
6,
ARTN e23872
Structural Characterization of the Early Events in the Nucleation-Condensation Mechanism in a Protein Folding Process
P Kukic, Y Pustovalova, C Camilloni, S Gianni, DM Korzhnev, M Vendruscolo
– Journal of the American Chemical Society
(2017)
139,
6899
Emergence and evolution of an interaction between intrinsically disordered proteins
G Hultqvist, E Åberg, C Camilloni, GN Sundell, E Andersson, J Dogan, CN Chi, M Vendruscolo, P Jemth
– eLife
(2017)
6,
ARTN e16059
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS
P Ciryam, IA Lambert-Smith, DM Bean, R Freer, F Cid, GG Tartaglia, DN Saunders, MR Wilson, SG Oliver, RI Morimoto, CM Dobson, M Vendruscolo, G Favrin, JJ Yerbury
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E3935
Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers.
P Varilly, AP Willard, JB Kirkegaard, TPJ Knowles, D Chandler
– The Journal of chemical physics
(2017)
146,
135102
MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions
Y Yoshimura, MA Holmberg, P Kukic, CB Andersen, A Mata-Cabana, SF Falsone, M Vendruscolo, EAA Nollen, FAA Mulder
– J Biol Chem
(2017)
292,
8269
Simultaneous quantification of protein order and disorder.
P Sormanni, D Piovesan, GT Heller, M Bonomi, P Kukic, C Camilloni, M Fuxreiter, Z Dosztanyi, RV Pappu, MM Babu, S Longhi, P Tompa, AK Dunker, VN Uversky, SCE Tosatto, M Vendruscolo
– Nature Chemical Biology
(2017)
13,
339
A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017)
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences
(2017)
114,
E2543
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.
O Sin, T de Jong, A Mata-Cabana, M Kudron, MA Zaini, FA Aprile, RI Seinstra, E Stroo, RW Prins, CN Martineau, HH Wang, W Hogewerf, A Steinhof, EE Wanker, M Vendruscolo, CF Calkhoven, V Reinke, V Guryev, EAA Nollen
– Molecular Cell
(2017)
65,
1096
Exciton Coupling of Phenylalanine Reveals Conformational Changes of Cationic Peptides
C Bortolini, L Liu, SV Hoffmann, NC Jones, TPJ Knowles, M Dong
– ChemistrySelect
(2017)
2,
2476
Acceleration of alpha-synuclein aggregation
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse
– Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
(2017)
24,
20
Investigation of Ionization Pattern of the Adjacent Acidic Residues in the DXDXE Motif of GH-18 Chitinases Using Theoretical pKa Calculations.
P Meekrathok, P Kukic, JE Nielsen, W Suginta
– J Chem Inf Model
(2017)
57,
572
Inhibition of alpha-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between alpha-Synuclein Species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades
– Biochemistry
(2017)
56,
1177
Widespread Proteome Remodeling and Aggregation in Aging C. elegans
DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo, M Mann, FU Hartl
– Cell
(2017)
168,
944
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E1009
Physical principles of filamentous protein self-assembly kinetics.
TCT Michaels, LX Liu, G Meisl, TPJ Knowles
– Journal of Physics: Condensed Matter
(2017)
29,
153002
Structural Investigation of an Immunoglobulin Domain on the Ribosome using NMR Spectroscopy
AME Cassaignau, HMM Launay, CA Waudby, T Wlodarski, M-E Karyadi, AL Robertson, X Wang, C Camilloni, M Vendruscolo, CA Woolhead, L Cabrita, J Christodoulou
– BIOPHYSICAL JOURNAL
(2017)
112,
41A
Effects of Amyloid-Beta Expression on Neuronal Signalling Pathways in a Novel C. elegans Model of Alzheimer's Disease
T Sinnige, P Ciryam, CM Dobson, M de Bono, M Vendruscolo
– BIOPHYSICAL JOURNAL
(2017)
112,
159A