Dr Seema Qamar

Research Associate

Publications

The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration

P St George-Hyslop, JQ Lin, A Miyashita, EC Phillips, S Qamar, SJ Randle, G Wang

– Brain Res

(2018)

1693,

(doi: 10.1016/j.brainres.2018.04.036)

Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1

PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows

– Cell

(2018)

(doi: 10.1016/j.cell.2018.03.056)

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop

– Cell

(2018)

173,

720

(doi: 10.1016/j.cell.2018.03.056)

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.

P Thornton, J Sevalle, M Deery, G Fraser, Y Zhou, S Ståhl, EH Franssen, RB Dodd, S Qamar, B Gomez Perez-Nievas, LSC Nicol, S Eketjäll, J Revell, C Jones, A Billington, PH St George-Hyslop, I Chessell, D Crowther

– EMBO Mol Med

(2017)

1179

(doi: 10.15252/emmm.201707673)

The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C.

AK Ho, JL Wagstaff, PT Manna, L Wartosch, S Qamar, EF Garman, SMV Freund, RC Roberts

– BMC Biology

(2016)

14,

109

(doi: 10.1186/s12915-016-0332-8)

NMR backbone resonance assignment and solution secondary structure determination of human NSD1 and NSD2

N Amin, D Nietlispach, S Qamar, J Coyle, E Chiarparin, G Williams

– Biomolecular NMR Assignments

(2016)

10,

315

(doi: 10.1007/s12104-016-9691-x)

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

T Murakami, S Qamar, JQ Lin, GSK Schierle, E Rees, A Miyashita, AR Costa, RB Dodd, FTS Chan, CH Michel, D Kronenberg-Versteeg, Y Li, S-P Yang, Y Wakutani, W Meadows, RR Ferry, L Dong, GG Tartaglia, G Favrin, W-L Lin, DW Dickson, M Zhen, D Ron, G Schmitt-Ulms, PE Fraser, NA Shneider, C Holt, M Vendruscolo, CF Kaminski, P St George-Hyslop

– Neuron

(2015)

88,

678

(doi: 10.1016/j.neuron.2015.10.030)