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Centre for Misfolding Diseases

Dr Pietro Sormanni

Pietro obtained his BSc and a MSc in theoretical physics at the University of Milan (Italy) and spent the final year of his BSc studies in London at Queen Mary University and UCL. In January 2016, he obtained a PhD in chemistry from the University of Cambridge, working under the supervision of Prof Michele Vendruscolo at the Centre for Misfolding Diseases, where he currently works as a postdoctoral researcher.


Pietro’s research focuses on the development and applications of computational methods to predict and modify the behaviour of proteins, with a particular interest in developing novel technologies for the rational design of antibodies for research and therapeutic purposes. He has published a number of research articles on the topic and filed two patents that are at the basis of numerous academic and industrial collaborations. 

Publications

Rapid and accurate in silico solubility screening of a monoclonal antibody library.
P Sormanni, L Amery, S Ekizoglou, M Vendruscolo, B Popovic
– Scientific reports
(2017)
7,
8200
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Sci Adv
(2017)
3,
e1700488
Simultaneous quantification of protein order and disorder.
P Sormanni, D Piovesan, GT Heller, M Bonomi, P Kukic, C Camilloni, M Fuxreiter, Z Dosztanyi, RV Pappu, MM Babu, S Longhi, P Tompa, AK Dunker, VN Uversky, SCE Tosatto, M Vendruscolo
– Nature Chemical Biology
(2017)
13,
339
A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017)
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences
(2017)
114,
E2543
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E1009
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimers disease
R Freer, P Sormanni, G Vecchi, P Ciryam, CM Dobson, M Vendruscolo
– Sci Adv
(2016)
2,
e1600947
Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
C Camilloni, BM Sala, P Sormanni, R Porcari, A Corazza, M De Rosa, S Zanini, A Barbiroli, G Esposito, M Bolognesi, V Bellotti, M Vendruscolo, S Ricagno
– Scientific reports
(2016)
6,
25559
Targeting disordered proteins with small molecules using entropy
GT Heller, P Sormanni, M Vendruscolo
– Trends in Biochemical Sciences
(2015)
40,
491
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
P Sormanni, FA Aprile, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
9902
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.
FA Aprile, P Sormanni, M Vendruscolo
– Biochemistry
(2015)
54,
5103
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Postdoctoral researcher

Telephone number

01223 336366 (shared)

Email address