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Centre for Misfolding Diseases

Dr Janet Kumita

I received an Honours B.Sc. in Biochemistry from the University of Waterloo (Canada) and completed my Ph.D. at the University of Toronto in the laboratory of Prof. G.A. Woolley, where my work involved investigating reversible photo-control of peptide structure and activity. In 2003, I was awarded a NSERC Postdoctoral Fellowship and joined the research group of Prof. C.M. Dobson in the Dept. of Chemistry, University of Cambridge, during which time I have been a Co-researcher Investigator on a BBRSC Project grant and am now a Senior Research Associate in the Centre for Misfolding Diseases. My research interests focus on studying the mechanisms of protein misfolding in globular proteins (specifically human lysozyme and disease-related variants), on a molecular level. We are also looking at different protein misfolding systems (Aβ1-42 and TDP-43) to probe the cellular mechanisms involved in protein misfolding and how biological molecules such as extracellular chaperones modify and influence these processes.

Publications

Amyloid-like Fibrils from an α-Helical Transmembrane Protein
K Stroobants, JR Kumita, NJ Harris, DY Chirgadze, CM Dobson, PJ Booth, M Vendruscolo
– Biochemistry
(2017)
56,
3225
Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.
R Zeineddine, DR Whiten, NE Farrawell, L McAlary, MA Hanspal, JR Kumita, MR Wilson, JJ Yerbury
– Prion
(2017)
11,
195
Inhibition of alpha-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between alpha-Synuclein Species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades
– Biochemistry
(2017)
56,
1177
The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.
M Ahn, CL Hagan, A Bernardo-Gancedo, E De Genst, FN Newby, J Christodoulou, A Dhulesia, M Dumoulin, CV Robinson, CM Dobson, JR Kumita
– Biophys J
(2016)
111,
2358
Structural Studies of the Oligomerization Process of Human Cystatin C Variants
Z Pietralik, M Murawska, A Szymanska, JR Kumita, CM Dobson, M Kozak
– BIOPHYSICAL JOURNAL
(2016)
110,
26A
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
114,
E200
Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide.
P Aran Terol, JR Kumita, SC Hook, CM Dobson, EK Esbjörner
– Biochemical and Biophysical Research Communications
(2015)
468,
696
The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution
Z Pietralik, JR Kumita, CM Dobson, M Kozak
– Colloids and surfaces. B, Biointerfaces
(2015)
131,
83
Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms.
P Kukic, HT Alvin Leung, F Bemporad, FA Aprile, JR Kumita, A De Simone, C Camilloni, M Vendruscolo
– Structure (London, England : 1993)
(2014)
23,
745
The interplay of protein aggregates, microglia and neuroinflammation in neurodegenerative disease
SC Hook, K Roberts, JR Kumita, JJ Yerbury
(2015)
157
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Senior postdoctoral researcher

Telephone number

01223 761083

Email address