Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
Mechanism of secondary nucleation from the direct observation of Aβ42 aggregation at the single fibril level
– Biophysical Journal
(2022)
121,
443A
(doi: 10.1016/j.bpj.2021.11.556)
Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease
– Alzheimer's & Dementia
(2022)
17,
(doi: 10.1002/alz.051680)
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.
– Life Sci Alliance
(2021)
5,
e202101270
(doi: 10.26508/lsa.202101270)
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation.
– ACS Chemical Neuroscience
(2021)
12,
4406
(doi: 10.1021/acschemneuro.1c00454)
Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.
– Front Mol Biosci
(2021)
8,
757425
(doi: 10.3389/fmolb.2021.757425)
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.
– Science advances
(2021)
7,
eabh1448
(doi: 10.1126/sciadv.abh1448)
Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules.
– ACS nano
(2021)
15,
18305
(doi: 10.1021/acsnano.1c07537)
Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation.
– J Am Chem Soc
(2021)
143,
16621
(doi: 10.1021/jacs.1c07228)
A conformational switch controlling the toxicity of the prion protein
(2021)
2021.09.20.460912
(doi: 10.1101/2021.09.20.460912)
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces
– Proceedings of the National Academy of Sciences of the United States of America
(2021)
118,
e2108790118
(doi: 10.1073/pnas.2108790118|1of8)
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