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Centre for Misfolding Diseases

Dr Farah El Turk

Research Associate

Publications

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations
I Dikiy, B Fauvet, A Jovičić, A-L Mahul-Mellier, C Desobry, F El-Turk, AD Gitler, HA Lashuel, D Eliezer
– ACS Chem Biol
(2016)
11,
2428
(doi: 10.1021/acschembio.6b00539)
Structural Effects of Two Camelid Nanobodies Directed to Distinct C‑Terminal Epitopes on α‑Synuclein
F El-Turk, FN Newby, E De Genst, T Guilliams, T Sprules, A Mittermaier, CM Dobson, M Vendruscolo
– Biochemistry
(2016)
55,
3116
(doi: 10.1021/acs.biochem.6b00149)
Elucidating the Structural Basis of α-Synuclein Fibrillation using Small Camelid Nanobodies
F El Turk, G Tomba, E De Genst, T Guillams, P Kukic, M Vendruscolo, C Dobson
– Biophysical Journal
(2014)
106,
257a
(doi: 10.1016/j.bpj.2013.11.1512)
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
– Journal of Molecular Biology
(2013)
425,
2397
(doi: 10.1016/j.jmb.2013.01.040)
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
– Journal of molecular biology
(2013)
425,
2397
(doi: 10.1016/j.jmb.2013.01.040)
Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket
F El-Turk, B Fauvet, A Ashrafi, H Ouertatani-Sakouhi, M-K Cho, M Neri, M Cascella, U Rothlisberger, F Pojer, M Zweckstetter, H Lashuel
– PloS one
(2012)
7,
e45024
(doi: 10.1371/journal.pone.0045024)
Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors with Distinct Mechanisms of Action*
H Ouertatani-Sakouhi, F El-Turk, B Fauvet, M-K Cho, D Pinar Karpinar, D Le Roy, M Dewor, T Roger, J Bernhagen, T Calandra, M Zweckstetter, HA Lashuel
– J Biol Chem
(2010)
285,
26581
(doi: 10.1074/jbc.m110.113951)
An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity
F El Turk, B Fauvet, H Ouertatani-Sakouhi, A Lugari, S Betzi, P Roche, X Morelli, HA Lashuel
– Bioorganic & medicinal chemistry
(2010)
18,
5425
(doi: 10.1016/j.bmc.2010.05.010)
Kinetic-Based High-Throughput Screening Assay to Discover Novel Classes of Macrophage Migration Inhibitory Factor Inhibitors
H Ouertatani-Sakouhi, M Liu, F El-Turk, GD Cuny, MA Glicksman, HA Lashuel
– SLAS Discovery
(2010)
15,
347
(doi: 10.1177/1087057110363825)
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor
H Ouertatani-Sakouhi, F El-Turk, B Fauvet, T Roger, D Le Roy, DP Karpinar, L Leng, R Bucala, M Zweckstetter, T Calandra, HA Lashuel
– Biochemistry
(2009)
48,
9858
(doi: 10.1021/bi900957e)
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