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Centre for Misfolding Diseases

Dr Aditi Narendra Borkar

My main research interests lie at the interface of experimental and theoretical techniques to obtain atomic-resolution understanding of the structure and dynamics of nucleo-protein complexes. During my Ph. D., I studied the dynamics of the HIV-1 TAR RNA using NMR spectroscopy data in combination with molecular dynamics simulations. For my postdoctoral research, I have now taken up the long-standing challenge of determining the structure of the whole HIV-1 ribonucleoprotein transactivation complex (TAC) by X-ray crystallography. 

Publications

Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop
AN Borkar, P Vallurupalli, C Camilloni, LE Kay, M Vendruscolo
– Physical chemistry chemical physics : PCCP
(2017)
19,
2797
Structure of a low-population binding intermediate in protein-RNA recognition.
AN Borkar, MF Bardaro, C Camilloni, FA Aprile, G Varani, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
7171
Constructing free energy landscapes of RNAs at atomic resolution and characterisation of their excited states
AN Borkar, P Vallurupalli, C Camilloni, LE Kay, M Vendruscolo
– JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2015)
33,
58
A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings.
AN Borkar, A De Simone, RW Montalvao, M Vendruscolo
– The Journal of chemical physics
(2013)
138,
215103
AUTOBA: Automation of backbone assignment from HN(C)N suite of experiments
A Borkar, D Kumar, RV Hosur
– Journal of Biomolecular NMR
(2011)
50,
285
Visualization of early events in acetic acid denaturation of HIV-1 Protease: A molecular dynamics study
AN Borkar, MK Rout, RV Hosur
– PLoS One
(2011)
6,
e19830
Structure and Dynamics of Double Helical DNA in Torsion Angle Hyperspace: A Molecular Mechanics Approach
A Borkar, I Ghosh, D Bhattacharyya
– Journal of Biomolecular Structure and Dynamics
(2010)
27,
695

Postdoctoral researcher

Telephone number

01223 336366 (shared)

Email address