Centre for Misfolding Diseases

Dr Farah El Turk

Research Associate

Publications

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations
I Dikiy, B Fauvet, A Jovičić, A-L Mahul-Mellier, C Desobry, F El-Turk, AD Gitler, HA Lashuel, D Eliezer
ACS Chem Biol
(2016)
11
(doi: 10.1021/acschembio.6b00539)
Structural Effects of Two Camelid Nanobodies Directed to Distinct C‑Terminal Epitopes on α‑Synuclein
F El-Turk, FN Newby, E De Genst, T Guilliams, T Sprules, A Mittermaier, CM Dobson, M Vendruscolo
Biochemistry
(2016)
55
(doi: 10.1021/acs.biochem.6b00149)
Elucidating the Structural Basis of α-Synuclein Fibrillation using Small Camelid Nanobodies
FE Turk, G Tomba, E De Genst, T Guillams, P Kukic, M Vendruscolo, C Dobson
Biophysical Journal
(2014)
106
(doi: 10.1016/j.bpj.2013.11.1512)
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E De Genst
Journal of Molecular Biology
(2013)
425
(doi: 10.1016/j.jmb.2013.01.040)
Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket
F El-Turk, B Fauvet, A Ashrafi, H Ouertatani-Sakouhi, M-K Cho, M Neri, M Cascella, U Rothlisberger, F Pojer, M Zweckstetter, H Lashuel
PloS one
(2012)
7
(doi: 10.1371/journal.pone.0045024)
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action
H Ouertatani-Sakouhi, F El-Turk, B Fauvet, M-K Cho, D Pinar Karpinar, D Le Roy, M Dewor, T Roger, J Bernhagen, T Calandra, M Zweckstetter, HA Lashuel
J Biol Chem
(2010)
285
(doi: 10.1074/jbc.M110.113951)
An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity
F El Turk, B Fauvet, H Ouertatani-Sakouhi, A Lugari, S Betzi, P Roche, X Morelli, HA Lashuel
Bioorg Med Chem
(2010)
18
(doi: 10.1016/j.bmc.2010.05.010)
Kinetic-Based High-Throughput Screening Assay to Discover Novel Classes of Macrophage Migration Inhibitory Factor Inhibitors
H Ouertatani-Sakouhi, M Liu, F El-Turk, GD Cuny, MA Glicksman, HA Lashuel
Journal of biomolecular screening
(2010)
15
(doi: 10.1177/1087057110363825)
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor
H Ouertatani-Sakouhi, F El-Turk, B Fauvet, T Roger, D Le Roy, DP Karpinar, L Leng, R Bucala, M Zweckstetter, T Calandra, HA Lashuel
Biochemistry
(2009)
48
(doi: 10.1021/bi900957e)
The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor.
F El-Turk, M Cascella, H Ouertatani-Sakouhi, RL Narayanan, L Leng, R Bucala, M Zweckstetter, U Rothlisberger, HA Lashuel
Biochemistry
(2008)
47
(doi: 10.1021/bi800603x)

Postdoctoral researcher

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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